基于网络的映射和神经递质架构的大脑灰质的外向相关联的外向
Hai-Hua Sun1, Hu-Cheng Yang2,3, Xiao-Yi Liu2
1Department of Geriatrics, Affiliated Hospital 6 of Nantong University, Yancheng Third People's Hospital, Yancheng, China.
与外向相关的灰色物质的结构变化一致地映射到默认模式网络 (DMN) 和前端平行网络 (FPN). 这些网络与特定的神经递质受体和传递器有着明显的关联,进步了我们对这种人格特征的理解.
科学领域:
- 神经科学是一个神经科学.
- 脑部成像 脑部成像
- 精神病学是一个精神病学.
背景情况:
- 外向,一个核心的人格特征,在以前的基于声素的形态学 (VBM) 研究中显示了异质灰质 (GM) 相关性.
- 了解这些结构变异的共同功能性大脑网络和神经化学支柱至关重要.
研究的目的:
- 确定与外向相关的转基因差异相关的常见功能性大脑网络.
- 描述这些已识别的网络中的神经递质受体和传送器架构.
主要方法:
- 一项系统的文献搜索确定了13项关于外向和转基因的VBM研究.
- 功能连接网络映射 (FCNM) 应用于来自人类连接组项目 (HCP) 和西南大学成人寿命数据集 (SALD) 的静止状态fMRI数据.
- 使用JuSpace工具箱分析了已识别的网络和神经递质分布之间的空间关系.
主要成果:
- FCNM揭示了外向转基因相关物汇聚到特定的功能网络上,主要是前端对象网络 (FPN) 和默认模式网络 (DMN).
- 这些网络与5-基三胺受体2A (5HT2a),大麻素受体类型-1 (CB1) 和甲基酸盐受体5 (mGluR5) 显示出显著的正相关性.
- 与北上腺素载体 (NAT) 和血清素载体 (SERT) 发现了负相关性.
结论:
- 尽管先前的VBM研究中存在区域异质性,但外向的结构性转基因相关物一致地映射到DMN和FPN上.
- 这种基于网络的方法调和了以前的不一致性,突出了DMN和FPN作为外向结构变化的关键基板.
- 研究结果表明,在这些网络中存在着独特的神经化学架构,从而推动了对外向神经基础的系统级理解.
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