附录素A1水平会影响健康中的微生物群和DSS诱导的大肠炎/炎症性肠病的发展
Luana Filippi Xavier1, Ranko Gacesa2,3, Gustavo Henrique Oliveira da Rocha4
1Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Frontiers in immunology
|October 20, 2025
概括
附件A1 (AnxA1) 在炎症性肠道疾病 (IBD) 中调节肠道微生物群中发挥作用. 安克斯A1 缺乏或低表达与小鼠和人类IBD患者的肠道失调有关.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 炎症性肠病 (IBD) 涉及肠道失调和免疫失调.
- 附件A1 (AnxA1) 有助于上皮的修复,并抑制IBD的免疫反应.
- 在IBD期间,AnxA1对肠道微生物群的特定影响尚不清楚.
研究的目的:
- 研究AnxA1在小鼠大肠炎期间对肠道微生物群组成的影响.
- 评估人类IBD患者的AnxA1表达水平和肠道微生物群之间的关联.
- 探索AnxA1在IBD中的免疫-微生物群轴中的作用.
主要方法:
- 在DSS诱导的大肠炎期间,从野生类型和AnxA1缺乏的小鼠获得便样本的16SrRNA测序.
- 来自生命线荷兰微生物组项目队列的人类微生物群数据的分析,与AnxA1表达相关.
- 在健康对照组,缺乏AnxA1的小鼠和具有不同AnxA1水平的IBD患者中对微生物特征的比较分析.
主要成果:
- 缺少AnxA1的小鼠显示微生物丰富性降低,微生物群组成不同,结肠炎症状加剧,微生物转移较早.
- 具有低AnxA1表达的人类IBD患者表现出改变的微生物群,富含Lachnoclostridium和Parabacteroides等特定细菌.
- 炎症克罗恩病患者的高AnxA1表达与与健康个体相似的微生物群概况相关,而低表达表明更明显的失生状态.
结论:
- 在健康和IBD状态下,AnxA1会影响肠道微生物群的组成.
- 安克斯A1缺乏或低表达与小鼠和人类IBD患者的肠道失调有关.
- 安克斯A1成为与IBD病原发生相关的免疫微生物群轴的潜在调节者.
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