人体中的微生物与上道泌尿瘤之间的关系是什么?
Xin Pei1, Minghui Yu1, Yijia Wang2
1Department of Urinary Surgery, China-Japan Union Hospital, Jilin University, Changchun, China.
Frontiers in immunology
|October 20, 2025
概括
人体微生物群,特别是尿路微生物群,在上道尿路癌 (UTUC) 的发展和进展中起着关键作用. 尿路细菌及其代谢物的变化为UTUC提供了潜在的诊断标记物和治疗点.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 上管尿路癌 (UTUC) 存在诊断和治疗方面的挑战.
- 人类微生物群因其在包括癌症在内的各种疾病中的作用得到越来越多的认可.
- 尿路微生物组研究为UTUC的病原体提供了新的见解.
研究的目的:
- 审查目前关于人类微生物组在UTUC中的作用的研究.
- 探索尿路微生物群影响尿路微生物群发展的机制.
- 确定微生物组研究在UTUC的潜在诊断和治疗应用.
主要方法:
- 对调查尿路微生物组和UTUC的研究进行文献综述.
- 对健康个体与UTUC患者的细菌组成的分析.
- 检查微生物组代谢物及其对瘤生物学的影响.
- 对UTUC诊断和预后的微生物标记物的评估.
主要成果:
- UTUC与致病性细菌 (如大肠杆菌) 的丰富以及尿道中开始性细菌的减少有关.
- 微生物组的变化通过慢性炎症,基因毒性损伤,免疫失调和代谢重编程,有助于UTUC的病变发生.
- 微生物代谢物可以调节免疫检查点和与癌症进展相关的代谢途径.
- 尿路微生物标记物和肠道菌群多样性指数显示出改善UTUC诊断,预测治疗反应和确定预后的潜力.
结论:
- 尿路微生物组在UTUC的发病过程中具有重要意义.
- 基于微生物组的策略有望提高UTUC的诊断和治疗.
- 需要进一步的研究来应对挑战,并推进基于微生物的UTUC管理.
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