病例报告:两例慢性活跃的爱斯坦-巴尔病毒病呈现为耐火性鼻炎的病例
Puyu Wang1, Dong Dong1, Shuman Huang1
1Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in immunology
|October 20, 2025
概括
慢性活跃的爱斯坦-巴尔病毒疾病 (CAEBV) 可以呈现为耐火性鼻炎. 化学抗原受体T细胞免疫疗法 (CAR-T) 显示出治疗这种罕见疾病的潜力,尽管结果各不相同.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 在瘤学瘤学.
背景情况:
- 慢性活跃的爱斯坦-巴尔病毒疾病 (CAEBV) 是一种罕见的系统性淋巴增殖性疾病.
- T细胞和/或NK细胞的EBV感染导致炎症和克隆增殖.
- 多样化的临床表现和诊断挑战导致预后不佳.
研究的目的:
- 报告两例系统性CAEBV病例,呈现为耐火性鼻炎.
- 评估这些CAEBV病例的治疗反应和结果.
- 突出CAR-T治疗CAEBV.的潜力.
主要方法:
- 两名耐火性鼻炎患者的病例报告.
- 诊断工作包括临床表现,病理学和EBV DNA测试.
- 治疗方法包括免疫疗法,化疗,CAR-T和干细胞移植.
主要成果:
- 两位患者都出现了耐火性鼻炎,发烧和鼻腔症状.
- 最初的治疗无效,两者都进展为血细胞淋巴细胞瘤 (HLH).
- 一名患者通过CAR-T疗法实现了缓解;另一个患者在干细胞移植后因并发症而死亡.
结论:
- 系统性CAEBV可以表现为耐火性鼻炎,造成诊断困难.
- 卡特-T疗法显示出作为CAEBV.治疗选择的前景.
- 这一案例系列强调了对CAEBV的早期诊断和量身定制的治疗策略的需要.
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