罗库-sugammadex与cisatracurium对运动唤起潜力的作用 (RECAP-MEP) - 一项随机对照试验
Sapna Suresh1, Ajay Prasad Hrishi2, Jithendra Thiruvathra1
1Anesthesia and Critical Care, Aster Medicity, Kochi, Kerala, India.
Surgical neurology international
|October 20, 2025
概括
在脊椎手术期间,与cisatracurium相比,Sugammadex逆转rocuronium改善了跨运动唤起潜能 (TcMEPs) 监测. 这导致了更好的MEP振幅和更快的恢复,而不会增加不利的运动.
科学领域:
- 麻醉学 麻醉学
- 神经外科 神经外科
- 脊髓监测 脊髓监测 脊髓监测
背景情况:
- 在脊柱外科手术期间,对手术内脊髓完整性的评估至关重要的是跨的运动唤起潜力 (TcMEPs).
- TcMEPs对神经肌肉阻断剂高度敏感,使其使用变得复杂.
- 本研究研究了不同神经肌肉阻塞策略对TCMEP监测的影响.
研究的目的:
- 为了比较与sugammadex逆转的罗库与cisatracurium对TcMEP振幅和恢复的影响.
- 在这两种麻醉方案下,评估胸部和腰椎手术期间MEP监测的质量.
主要方法:
- 一个双盲,随机对照试验,涉及60名接受选择性脊柱手术的患者.
- 患者接受了罗库与苏加马德克斯逆转或cisatracurium.
- 主要结局包括在神经肌肉阻塞逆转后的各种时间点上的MEP振幅和延迟测量.
主要成果:
- 与cisatracurium组相比,rocuronium-sugammadex组显示出明显更高的MEP幅度和更短的MEP延迟时间.
- 在rocuronium-sugammadex组中,四人列车 (TOF) 恢复明显更快.
- 在罗库 - 苏加马德克斯组中,尽管使用了较高的普罗波剂量,但没有观察到手术内运动的统计学上显著增加.
结论:
- 与cisatracurium相比,由sugammadex促进的罗库的逆转提供了优越的MEP参数 (振幅,延迟).
- 这种改善的监测质量是没有显著增加不良运动实现的.
- 这些发现支持使用罗库与sugammadex用于加强脊椎外科手术中的TCMEP监测.
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