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模仿质母细胞瘤的中枢神经系统瘤原发性血管炎:基于病例的系统性审查

Ghaida M Fatani¹, Marwa A Aljehani², Ebtesam S Alshehri¹

¹Department of Neurosciences, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.

Surgical neurology international

|October 20, 2025

概括

中枢神经系统 (PACNS) 的原发性血管炎可以在成像上模仿质母细胞瘤,延迟诊断. 组织学确认对于这种罕见的疾病至关重要,虽然免疫抑制是有效的,但需要标准化的治疗方案.

科学领域:

神经学神经学
病理学病理学病理学
放射学放射学是一门学科.

背景情况:

中枢神经系统的初级血管炎 (PACNS) 是一种罕见的炎症状况,影响中枢神经系统的血管.
由于非特异性症状和成像发现,PACNS诊断具有挑战性,通常模仿质母细胞瘤.
这项研究突出了瘤性PACNS被误诊为结质母细胞瘤的病例,并审查了类似的病例.

研究的目的:

为了评估 tumefactive PACNS 的诊断变异性.
分析模仿质母细胞瘤的PACNS的临床和放射性特征.
为了评估PACNS的治疗结果.

主要方法:

根据PRISMA指南,对已公布的PACNS案件 (2000-2023) 进行了系统审查.
鉴定和分析了34例模仿质母细胞瘤的瘤状PACNS病例.
收集的数据包括人口统计,成像特征,组织学和治疗管理.

主要成果:

审查发现了34例瘤活性PACNS的病例,平均年龄为35.92岁.
常见的表现包括焦点神经缺陷 (71%) 和头痛 (19%);MRI经常显示T2高强度病变与.
组织病理学揭示了淋巴细胞或粒状血管炎;免疫抑制疗法 (类固醇,环胺) 显示了74%的反应率,但26%的复发.

结论:

瘤性PACNS经常在放射学上模仿质母细胞瘤,这强调了组织学确认的必要性.
免疫抑制疗法是有效的,但缺乏标准化的治疗方案.
建议对生物标志物和先进成像进行进一步的研究,以改善PACNS的诊断和治疗.

关键词:

质母细胞瘤 (glioblastoma) 是一个高度质瘤高度质瘤磁共振成像技术磁共振成像技术类似质量的病变.中枢神经系统的主要血管炎.Sarcoidosis 是一种癌症.系统性审查系统性审查瘤作用性病变的发生.类似瘤的病变

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