非洲国家瘤临床试验的模式:一个范围审查
Kumban Walter Chuck1, Tung Hoang1,2, Jeongseon Kim1
1Department of Cancer AI and Digital Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.
Journal of cancer prevention
|October 20, 2025
概括
非洲的瘤临床试验活动正在增长,大多数试验在ClinicalTrials.gov.gov上注册. 然而,公布的结果仍然很少,这表明需要在整个非洲大陆改进试验登记和报告.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 公共卫生 公共卫生
背景情况:
- 非洲参与临床试验的比例正在增加.
- 关于非洲瘤临床试验注册趋势的文献有限.
- 了解这些趋势对于推动非洲大陆的癌症研究至关重要.
研究的目的:
- 审查2000年至2024年在非洲进行的瘤临床试验的模式和趋势.
- 分析主要注册表中的试验注册数据.
- 为了确定常见的癌症类型,研究设计和非洲瘤学试验的阶段.
主要方法:
- 数据从三个主要注册表中提取:泛非洲临床试验注册表 (PACTR),临床试验.gov (CTG) 和国际标准随机对照试验号码 (ISRCTN).
- 使用微软Excel进行了描述性分析.
- 检查了试验注册的趋势,研究设计,癌症类型,阶段和数据完整性的趋势.
主要成果:
- 临床试验.gov (CTG) 的注册人数最多 (n=458),其次是PACTR (n=148) 和ISRCTN (n=69).
- 2010年后试验活动增加,在2018-2019年达到顶峰,埃及,阿尔及利亚和南非领先于注册.
- 随机设计占主导地位 (80%以上),乳腺癌和宫癌是最受研究的,但发表的结果有限. 数据的完整性因注册表而异.
结论:
- 非洲的瘤临床试验活动显示出积极的上升趋势.
- 尽管注册数量增加,但在发表试验结果方面存在重大差距.
- 加强试验注册实践和促进及时出版对于非洲的癌症研究至关重要.
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