与健康对照组进行比较:对中国患有刺激性肠综合征的患者肠道菌群变化的元分析
Hao Tu1, Jingwen Xu1, Liping Wei2
1Department of Neurology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China.
Frontiers in cellular and infection microbiology
|October 20, 2025
概括
这项研究发现,在中国患有刺激性肠综合征 (IBS) 的患者中,肠道微生物群存在差异. 与健康个体相比,中国IBS患者的肠道细菌和肠球菌较高,乳酸菌和双菌较低.
科学领域:
- 微生物组研究 微生物组研究
- 胃肠病学 胃肠病学
- 人类健康 人类健康 人类健康
背景情况:
- 在中国易肠综合征 (IBS) 患者的肠道微生物特征尚未得到充分了解.
- 现有研究表明结果各不相同,缺乏关于IBS相关微生物变化的一致结论.
- 地理差异可能会影响IBS中独特的微生物特征,提供潜在的诊断和治疗途径.
研究的目的:
- 与健康对照组 (HC) 相比,研究中国IBS患者肠道微生物组的不同组成.
主要方法:
- 使用来自PubMed,Web of Science,Embase和CNKI数据库的数据进行了系统的元分析.
- 包括的研究是病例控制,重点是根据罗马标准诊断出IBS的中国人群.
- 数据分析涉及计算标准化平均差异 (SMD) 和95%置信区间 (CI),使用基于异质性的随机或固定效应模型.
主要成果:
- 与HC相比,中国IBS患者的Enterobacter和Enterococcus丰度显著更高.
- 在中国IBS患者中观察到乳酸菌和双菌的显著减少.
- 腹性IBS (IBS-D) 亚组显示细菌体减少,与IBS-便秘 (IBS-C) 患者不同.
结论:
- 这一元分析强调了中国IBS患者显著的肠道失调.
- 肠道细菌和肠球菌的增加,以及乳酸菌和双菌的减少,是中国IBS患者肠道微生物群的特征.
- 特定的变化,包括IBS-D的细菌体减少,表明有针对性的微生物干预措施.
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