在不同葡萄糖状态下,肥胖状况和神经精神健康和大脑结构变化之间的关联
Ping Chen1,2, Pan Zhang3, Zhiwei Lin1,2
1Department of Neurology, The First Hospital of Putian City, Putian, China.
Frontiers in nutrition
|October 20, 2025
概括
肥胖,特别是持续或增加的肥胖,会损害心理健康和大脑结构,其影响因葡萄糖控制而有所不同. 早期控制体重和新陈代谢可以预防大脑衰老和精神疾病.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 肥胖是一个全球性健康问题,与心脏代谢和神经精神疾病有关.
- 炎症和胰岛素抵抗等机制将肥胖与这些疾病联系起来.
- 了解脂肪和血糖状况如何影响大脑健康至关重要.
研究的目的:
- 研究肥胖指标,肥胖状况的变化和神经精神疾病之间的关联.
- 为了检查肥胖对不同血糖状况 (正常葡萄糖调节,糖尿病前期,糖尿病) 的大脑结构的影响.
- 为了澄清血糖状况如何改变肥胖和大脑健康之间的关系.
主要方法:
- 使用了英国生物库数据 (n=423,750; 32,551用脑MRI).
- 评估肥胖指标 (BMI,WC,BFP) 和肥胖状况的变化.
- 根据血糖状况分层参与者 (NGR,PRE-DM,DM) 并使用Cox/线性回归模型.
主要成果:
- 在所有血糖指标组中,较高的肥胖指标增加了抑郁和焦虑风险.
- 持续的肥胖和体重增加与正常葡萄糖调节中的更高的抑郁/焦虑风险有关.
- 在糖尿病患者中,较高的体脂百分比与大脑体积 (灰质,丘脑,海马) 的减少和白质超强度 (WMHs) 的增加有很强的相关性.
结论:
- 肥胖,特别是持续或不断增加,会对神经心理健康和大脑结构产生负面影响.
- 血糖状况显著改变了这些与肥胖相关的风险.
- 体重管理和代谢控制对于预防神经精神疾病和缓解大脑衰老至关重要.
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