昼夜节律扰乱对大鼠良性前列腺增生症的影响
Xiaoxue Huang1, Xiaohu Tang2, Yuanzhao Xu2,3
1Guizhou University, GuiZhou University Medical College, Guiyang, Guizhou, China.
PeerJ
|October 20, 2025
概括
扰乱的昼夜节律通过增加前列腺生长和改变免疫反应,加速大鼠良性前列腺增生 (BPH) 的发展. 这表明CRD是BPH的危险因素.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 内分泌学 在内分泌学.
- 时间生物学 时间生物学
背景情况:
- 良性前列腺增生 (BPH) 是一种与衰老,炎症和荷尔蒙变化有关的普遍疾病.
- 扰乱的昼夜节律 (CRD) 与这些BPH相关的因素有关.
- 这项研究调查了CRD对BPH发育的直接影响.
研究的目的:
- 为了确定是否被破坏的昼夜节律加速前列腺增生在老鼠模型.
- 探索CRD对前列腺组织的影响背后的分子机制.
主要方法:
- 使用丸和雌激醇颗粒建立了一个BPH老鼠模型.
- 通过持续暴露于光线 (Cle) 诱导CRD或维持12小时的光/12小时的黑暗周期 (Con).
- 分析前列腺体重,前列腺指数 (PI),血清激素水平,基因表达 (qRT-PCR,RNA-Seq),并进行组织学分析 (H&E,IHC为Ki-67).
主要成果:
- 与对照组相比,CRD显著增加了前列腺体重,PI和上皮厚度.
- CRD增加了二测试 (DHT) 和降低了雌激醇 (E2) 血清水平.
- 基因表达分析显示,CRD改变了昼夜节律基因,并丰富了与免疫反应,细胞因子-细胞因子受体相互作用和化学因子信号传递相关的途径.
结论:
- 被扰乱的昼夜节律加速前列腺增生在老鼠.
- CRD调节免疫和炎症反应,有助于BPH的发展.
- CRD成为加速BPH进展的潜在风险因素.
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