化疗期间瘤血流的动态变化:胰腺癌定制治疗的含义
Hiromitsu Maehira1, Takeru Maekawa1, Yoshihisa Tsuji2
1Department of Surgery, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan.
Oncology letters
|October 20, 2025
概括
瘤血流 (TBF) 可以预测胰腺癌中新辅助化疗反应. 高TBF受益于修改后的FOLFIRINOX,而gemcitabine加上nab-paclitaxel可能会改善低TBF瘤.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 胰腺管道腺癌 (PDAC) 是一种致命的癌症,在选择新辅助化疗 (NAC) 方面存在挑战.
- 瘤血流 (TBF) 与化疗反应有关,但其在特定疗程中的作用尚不清楚.
研究的目的:
- 调查前治疗TBF与PDAC中不同NAC疗程的治疗病理反应之间的关联.
- 评估NAC对TBF的影响及其与瘤内血管性的相关性.
主要方法:
- 对接受NAC和胰腺切除的58名PDAC患者的回顾性分析.
- 使用对比度增强计算机断层扫描进行TBF的量化.
- 将TBF分为高和低的治疗前群体进行分层,并评估治疗方案特定的结果.
主要成果:
- 较高的治疗前TBF与更好的病理反应相关 (P=0.027).
- 高TBF预测修改后的FOLFIRINOX (P=0.010) 的反应有所改善,但不是gemcitabine加NAB-paclitaxel (GnP) 或gemcitabine加S-1 (GS).
- 在低TBF患者治疗后GnP增加了TBF (P=0.004);治疗后TBF与专利容器相关 (r=0.486,P<0.001).
结论:
- 在PDAC中,TBF可以作为NAC选择的预测生物标志物.
- 高TBF表明修改后的FOLFIRINOX具有更好的疗效.
- 通过在治疗期间增强输液,GnP可能有利于低TBF瘤.
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