老年人8分数预测了老年人上部胃肠道瘤内镜切除后的功能衰退:一个前性队列研究
Yuki Okubo1, Takahiro Inoue1,2, Shunsuke Yoshii1
1Department of Gastrointestinal Oncology Osaka International Cancer Institute Osaka Japan.
DEN open
|October 20, 2025
概括
在为上部胃肠道瘤进行内切除的老年患者中,低的手术前老年8 (G8) 评分预测功能衰退. 这一发现有助于风险分层的老年人做出更好的治疗决策.
科学领域:
- 老年医学 老年医学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 内镜切除 (ER) 是对老年人上部胃肠道 (UGI) 瘤的微创治疗方法,提供了良好的短期结果.
- 然而,ER对该人群的功能结果的长期影响尚不清楚.
研究的目的:
- 在75岁及以上的患者中确定ER后功能衰退的预测因子.
- 评估各种老年医学评估工具在预测后ER功能结果方面的有用性.
主要方法:
- 一项前性,单中心的队列研究,涉及202名75岁以上的75名患者,他们因UGI瘤接受了ER.
- 使用迷你精神状态检查 (MMSE) 和日常生活仪器活动 (IADL) 尺度进行了认知和身体功能评估.
- 分析了包括老年人8 (G8) 在内的老年人评估工具的预测价值.
主要成果:
- 功能性下降 (≥3点MMSE或≥1点IADL下降) 发生在18.3%的患者 (37/202).
- 低的手术前G8分数 (≤14) 被确定为功能衰退的独立风险因素 (OR:2.64,p=0.0461).
- 一个显著的趋势显示,随着G8分数的下降,功能衰退越来越大 (p=0.0086).
结论:
- 术前G8评分可以预测UGI新生瘤的ER接受的老年患者的功能衰退.
- 将G8评估纳入术前评估可以支持基于风险的治疗决策,优化这个脆弱群体的功能结果.
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