相关实验视频
Updated: Jan 14, 2026

07:38
Strategies for Assessing Autistic-Like Behaviors in Mice
Published on: September 20, 2024
2.2K
自闭症谱系障碍背后的神经认知机制:文献综述
Shixian Liu1, Dongmei Zeng1, Caiying Yi1
1Department of Pediatric Neurological Rehabilitation, Ganzhou Women and Children Health Hospital, Ganzhou, Jiangxi, China.
Frontiers in psychiatry
|October 20, 2025
概括
自闭症谱系障碍 (ASD) 涉及影响认知和感官处理的大脑变化. 整合遗传学和神经成像技术有助于为这种复杂的疾病提供个性化治疗.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 发展生物学 发展生物学
背景情况:
- 自闭症谱系障碍 (ASD) 呈现出复杂的神经认知变化,影响社会认知,执行功能和感官处理.
- 了解底层机制对于推进ASD的诊断和治疗策略至关重要.
研究的目的:
- 对最近关于ASD的发现进行综合性审查.
- 通过跨学科的方法检查神经发育和功能影响ASD病理生理学的调节机制.
主要方法:
- 结构神经成像,功能连接,分子生物学,认知研究,遗传学和表观遗传学的综合性审查.
- 综述跨学科的方法来调查神经发育和功能在ASD.
主要成果:
- 神经成像揭示了ASD中的结构性大脑变化和中断的神经连接.
- 神经递质失调 (Glutamatergic,GABAergic) 导致激发抑制失衡,这是ASD的一个关键特征.
- 遗传和表观遗传因素,包括基因环境相互作用,影响ASD的神经发育.
结论:
- 整合成像,分子生物学和遗传学的多维框架对于理解ASD至关重要.
- 自闭症异质性需要个性化治疗策略.
- 未来的研究应该专注于早期生物标志物识别和自闭症个性化疗法.
相关概念视频
Autism Spectrum Disorder
962
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
962
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
1.8K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.8K
Biological Causes of Schizophrenia
486
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
486
Attention-Deficit/Hyperactivity Disorder
743
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
743
Social Anxiety Disorder
436
Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
436
Modeling in Therapy
378
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
378

