重度药物诱导的牙腺缩的外科治疗:一个案例报告
John J Alfarone1, Adam Hatala2, Dhruv Patel2
1Norton College of Medicine SUNY Upstate Medical University Syracuse New York USA.
Clinical case reports
|October 20, 2025
概括
严重的牙扩张发生在儿童移植患者中,由于他克罗利斯和尼菲迪平等药物. 手术干预是必要的,以恢复功能和改善生活质量.
科学领域:
- 药理学 药理学是指药理学的学科.
- 口腔医学是指口腔医学.
- 移植免疫学 移植免疫学
背景情况:
- 药物诱导的牙扩大 (DIGE) 是药物的已知的不良影响,包括管阻断剂,免疫抑制剂和抗药.
- 儿童移植患者通常需要复杂的免疫抑制疗法和抗高血压药物,增加DIGE的风险.
研究的目的:
- 报告儿童移植患者药物诱导的严重牙扩大病例.
- 突出在免疫抑制患者中管理DIGE的挑战以及手术干预的重要性.
主要方法:
- 一个15岁的男性患有脏移植后末期脏疾病的病例报告.
- 详细描述患者的药物治疗方案 (塔克罗利斯,普雷迪尼松,美可酸莫菲蒂尔,胸球蛋白,尼菲迪平).
- 临床检查,成像,牙组织的手术脱皮,桃体切除术和组织病理学分析.
主要成果:
- 患者出现了严重的牙扩张,导致功能受损,体重减轻,睡眠呼吸障碍.
- 手术脱皮和桃体切除术导致显著的临床改善,包括体重增加和恢复口服.
- 组织病理学证实了与DIGE一致的纤维素瘤.
结论:
- 儿科移植患者的严重DIGE需要多学科的方法,并且通常需要进行手术管理.
- 早期识别和干预对于恢复功能和改善这些复杂患者的生活质量至关重要.
- 免疫抑制剂,通道阻断剂和口腔健康之间的相互作用在移植后的护理中至关重要.
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