时代型,认知结果和神经动态:最近的证据和潜在的机制,对外科手术前期有影响
Ying Liu1, Qijing Liu1, Boxiong Gao1
1The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China.
Frontiers in neuroscience
|October 20, 2025
概括
睡眠时间型通过调节昼夜节律和神经炎症来影响认知功能. 外科手术期间的昼夜失调可能会使术后认知功能障碍 (POCD) 恶化,这凸显了针对性干预的必要性.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 时间生物学 时间生物学
背景情况:
- 循环节律调节重要的生物功能,包括睡眠和清醒周期,激素分泌和认知表现.
- 睡眠时间型,一个人对睡眠时间的偏好,与大脑结构和功能有关,可能会影响认知能力.
- 术后认知功能障碍 (POCD) 是一个越来越大的问题,而外科手术期间的昼夜干扰成为一个显著的贡献因素.
研究的目的:
- 审查睡眠时间型和认知功能之间的关系.
- 为了检查外科手术期间的昼夜变化对认知功能的影响.
- 探索潜在的治疗策略,以减轻与昼夜干扰相关的POCD.
主要方法:
- 文献综述侧重于研究睡眠时刻型,认知功能和外科手术后期结果的研究.
- 分析证据,将昼夜节律调节,神经炎症和代谢平衡与认知表现联系起来.
- 综合当前关于睡眠结构改变及其与POCD相关的研究.
主要成果:
- 时间型通过昼夜节律调节,神经炎症路径和代谢调节影响认知功能.
- 外科手术期间的睡眠障碍,包括缓慢波睡眠 (SWS) 减少和昼夜失调,可以加剧认知缺陷和神经炎症.
- 有证据表明,外科手术期间的昼夜失调与POCD的发展或恶化之间存在很强的联系.
结论:
- 睡眠时刻型是影响认知功能和对POCD易感性的关键因素.
- 在外科手术期间保持昼夜调整对于保持认知健康至关重要.
- 对睡眠模式和POCD机制的进一步研究可能会揭示新的治疗点.
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