在全身性疾病中,HMGB1介导的铁衰的参与
Lijie Lv1, Yue Wang2, Xuan Lv3
1Department of Rehabilitation, Lequn Branch, The First Hospital of Jilin University, Changchun, China.
Frontiers in cell and developmental biology
|October 20, 2025
概括
高流动性组盒1 (HMGB1) 调节铁,一种细胞死亡形式. HMGB1的双重作用影响瘤和非癌症疾病,提供治疗点.
科学领域:
- 生物化学和分子生物学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 铁亡是依赖铁的细胞死亡,以脂质过氧化和氧化还原失衡为标志.
- 高流动性组盒1 (HMGB1) 是一种具有免疫调节作用的核蛋白,成为铁亡相关疾病的关键调节者.
- HMGB1作为下游效应器和上游放大器,影响炎症,免疫力和新陈代谢.
研究的目的:
- 综合审查HMGB1诱导的铁灭的分子机制.
- 检查HMGB1-ferroptosis轴在瘤与非新生病中的双重作用.
- 讨论针对疾病特定干预的针对HMGB1-ferroptosis轴的治疗策略.
主要方法:
- 关于分子机制的文献综述.
- 分析HMGB1在通过自 - 铁氨和氧化还原信号调节中的作用.
- 检查HMGB1-ferroptosis轴在全身性疾病中的参与.
主要成果:
- HMGB1表现出取决于背景的作用:促进瘤中的抗瘤免疫力,但在非新发性条件下加剧损伤.
- HMGB1通过包括自 - 费里丁和氧化还原信号传递在内的途径调节铁.
- HMGB1-ferroptosis轴与广泛的系统性疾病有关.
结论:
- HMGB1是铁亡的关键调节者,在癌症和非癌症疾病中具有相反的影响.
- 针对HMGB1-ferroptosis轴为新的治疗干预提供了潜力.
- 调节铁亡,炎症和免疫的特定疾病策略对于有效的治疗至关重要.
相关概念视频
01:16Necrosis
6.2K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
6.2K
01:57Gene Families
9.7K
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
9.7K
01:22Lysosomal Hydrolases
4.4K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
4.4K
02:21Globular and Fibrous Proteins
46.6K
Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
46.6K
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
354
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
354
01:31Translation
154.9K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
154.9K