高分辨率的结构连接调解了与年龄相关的功能连接和流体认知的差异
Jenna L Merenstein1,2, Allen W Song2,3, David J Madden2,4
1Department of Psychology, University of Utah, Salt Lake City, UT 84112, USA.
Brain communications
|October 20, 2025
概括
与标准方法相比,高分辨率扩散加权成像更好地揭示与年龄相关的白质变化,影响大脑功能和认知. 这种先进的技术增强了对成年人一生的认知衰退的理解.
科学领域:
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
- 人类寿命研究研究 人类寿命研究
背景情况:
- 与年龄相关的认知衰退与白质降解有关.
- 更高分辨率的扩散权重成像可能比标准分辨率提供更精确的白质连接性估计.
研究的目的:
- 使用标准与高分辨率扩散权重成像来比较与年龄相关的白质结构连接性差异.
- 评估这些措施解释与年龄相关的功能连接和认知变化的能力.
主要方法:
- 对140名健康成年人 (18-88岁) 的横截面研究.
- 获得的标准和高分辨率的扩散权重成像和静止状态的功能性MRI.
- 使用图形理论评估认知 (记忆,执行功能,感知运动速度) 和连接性.
主要成果:
- 高分辨率成像显示,与年龄相关的感觉运动,腹部注意力和皮层下网络的衰退更大.
- 与年龄相关的功能连接性下降是由默认模式网络中的高分辨率结构连接性介导的.
- 高分辨率成像通过网络内连接,独特地调解了与年龄相关的流体认知下降.
结论:
- 高分辨率扩散加权成像更好地捕捉与年龄相关的白质变化.
- 这些变化限制了与年龄相关的大脑功能和认知表现的改变.
- 研究结果强调了成像分辨率对于研究认知衰老的重要性.
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