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Updated: Jun 14, 2026

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
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在功能性麻和脊髓损伤的个体中重温运动抑制

Vanessa Vallesi1,2,3, Cécile Galléa4, Jothini Sritharan2,3,5

  • 1Support Centre for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.

Brain communications
|October 20, 2025
PubMed
概括

功能性 (FP) 和脊髓损伤 (SCI) 在运动抑制中具有相似的神经模式,表明症状,而不是疾病本身,驱动这些大脑差异. 这表明异常的边缘驱动可能会影响的运动启动.

关键词:
功能连接性的功能连接性功能性神经系统疾病 功能性神经系统疾病去/没有去去.脊髓损伤导致的脊髓损伤基于任务的fMRI.

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...