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相关概念视频

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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从玻璃眼治疗中解码角膜内皮损失:一个病例控制分层分析分析.

Christopher D Yang1, Blaze Ann C Carbonell1, Vincent Hussey1

  • 1Department of Ophthalmology, Gavin Herbert Eye Institute, UC Irvine Health, Irvine; University of California, Irvine School of Medicine, Irvine, California, United States.

Journal of current glaucoma practice
|October 20, 2025
PubMed
概括

眼的治疗方法,包括滴液和手术,显著降低角膜内皮细胞密度. 罗相关蛋白激酶抑制剂导致最多的细胞损失,影响角膜健康.

关键词:
角质内皮的内皮是什么?内皮细胞密度 内皮细胞密度眼光障碍 眼光障碍 眼光障碍 眼光障碍青光眼治疗药物 青光眼药物玻璃眼外科手术 玻璃眼外科手术

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科学领域:

  • 眼科医生 眼科 眼科
  • 角质科学 角质科学
  • 玻璃眼研究研究 玻璃眼研究

背景情况:

  • 玻璃眼是导致不可逆转失明的主要原因.
  • 角膜内皮细胞对于保持角膜清晰度和功能至关重要.
  • 青光眼治疗对角膜内皮的影响需要进一步描述.

研究的目的:

  • 为了量化角膜内皮形态在绿眼患者和对照.
  • 评估各种青光眼治疗对内皮细胞密度 (ECD),变化系数 (CV) 和六角性 (Hex) 的影响.

主要方法:

  • 一项涉及304只眼睛的病例控制研究.
  • 在体内镜像显微镜使用Konan NSP-9000.
  • 手动分级和CellChek软件分析中枢角膜内皮图像.

主要成果:

  • 青光眼的ECD显著低于对照和青光眼的疑似眼睛.
  • 局部玻璃眼滴,管切除术和管道分流手术与减少的ECD有关.
  • 阿尔法激动剂,碳酸酶抑制剂 (CAI) 和Rho相关蛋白激酶 (ROCK) 抑制剂独立预测了显著的ECD减少,而ROCK抑制剂显示出最大的影响.

结论:

  • 青光眼的治疗方法,包括局部滴剂和外科手术,对角膜内皮细胞密度产生负面影响.
  • 某些类型的青光眼药物,特别是ROCK抑制剂,与大量的内皮细胞损失有关.