与子宫内膜异位症相关的不孕症:对病原和精密治疗方法的多学科见解
Yuyi Ou1, Hao Wang1, Cankun Zhou1
1Department of Gynecology, Foshan Women and Children Hospital Affiliated to Guangdong Medical University, Foshan, China.
Frontiers in endocrinology
|October 20, 2025
概括
子宫内膜异位症通过荷尔蒙,免疫,氧化,遗传和微生物组因素损害生育能力. 整合多组学揭示了新的生物标志物和精确治疗方法,以改善生殖结果.
科学领域:
- 生殖医学 生殖医学
- 遗传学和表观遗传学
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 子宫内膜异位症是一种常见的,依赖于雌激素的炎症性疾病,影响生育能力.
- 它涉及荷尔蒙失调,免疫功能障碍,氧化应激,遗传/表观遗传变化和微生物组失衡.
研究的目的:
- 综合多方面的研究和关于子宫内膜异位症相关不孕机制的临床证据.
- 评估与子宫内膜异位症相关的不孕症的当前和新兴治疗策略.
主要方法:
- 系统审查最近的多主题和临床证据.
- 机械学发现与临床影响的整合.
- 治疗目标,生物标志物和精确护理机会的映射.
主要成果:
- 关键机制包括雌激素主导,孕激素抵抗,免疫失调,铁,遗传/表观遗传变化和微生物组失调.
- 子宫内膜异位症会对卵巢储备,卵细胞能力,子宫内膜受体和盆腔解剖产生负面影响,降低生育能力.
- 目前的治疗方法 (手术,激素抑制,ART) 的疗效有变化;辅助疗法和生物标志物发现显示出有前途.
结论:
- 与子宫内膜异位症相关的不孕症是多因素的,具有相互关联的发病因子.
- 多学科的整合对于识别新生物标志物和治疗点至关重要.
- 需要精准医学方法来实现个性化治疗和改善生殖结果.
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