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Updated: Jan 14, 2026

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从扩散权重核磁共振和18F-氧葡萄糖PET/CT在头部和部状细胞癌中获得的功能参数之间的关系:系统性审查和元分析

Ludovico Maria Garau¹, Marco Rensi¹, Livio Bastianutti¹

¹Department of Nuclear Medicine, Santa Maria della Misericordia University Hospital, Udine, Italy.

International archives of otorhinolaryngology

|October 20, 2025

概括

在头癌中,有限的水分扩散与较高的葡萄糖吸收相关. 这次元分析发现,明显扩散系数和标准化吸收值之间存在显著的反向关系,这表明治疗监测的潜力.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
医疗成像医学成像

背景情况:

一个假设将降低水的扩散性与头癌的葡萄糖吸收增加联系在一起.
这种关系可能反映了瘤细胞密度和代谢活性.

研究的目的:

系统地审查和元分析研究,将扩散权重的MRI显微扩散系数 (ADC) 与18F-氧葡萄糖正子发射断层扫描/计算机断层扫描 (FDG-PET/CT) 在头癌中标准化吸收值 (SUV) 相对应.
评估这些功能成像参数之间的关联的强度和一致性.

主要方法:

通过PubMed通过MEDLINE系统地搜索相关研究的文献.
使用费舍尔Z转换的加权相关系数 (ρ) 的元分析.
使用希金斯不一致指数评估异质性,并通过漏斗图表评估出版偏差.

主要成果:

分析了涉及790名患者的25篇文章.
13项研究 (367名患者) 显示了统计学上显著的反相关性,其聚合相关系数为 ρ = -0.55 (95% CI: -0.624至 -0.473).
在报告显著相关性的研究中观察到较低的异质性.

结论:

在头癌中观察到的ADC和SUV之间的反相关性表明开发成像生物标志物的潜力.
这些指标可以帮助评估治疗疗效和预测临床结果.
发现的变化可能归因于瘤异质性或不同的临床背景.

关键词:

表面扩散系数的明显扩散系数扩散权重磁共振成像技术的扩散权重磁共振成像头部和部状细胞癌瘤定子发射断层扫描和计算机断层扫描.

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