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探索印尼POAG的眼球输液和结构变化:来自OCTA和OCT分析的见解

Raden Maula Rifada¹, Lina Shabrina Qorib¹, Iffa Nadifa Riza Hardjasasmita¹

¹Department of Ophthalmology, Faculty of Medicine, Universitas Padjadjaran-Cicendo Eye Hospital, Bandung, West Java, Indonesia.

Journal of current glaucoma practice

|October 20, 2025

概括

主要开角青光眼 (POAG) 与减少的周包膜视网膜 perfusion 密度和流量指数有关,与较薄的视网膜神经纤维层 (RNFL) 厚度相关. 这些血管变化对于POAG诊断和管理至关重要.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
玻璃眼研究研究玻璃眼研究

背景情况:

主要开角青光眼 (POAG) 是不可逆转失明的主要原因.
早期发现和监测POAG对于控制疾病进展至关重要.
了解眼 perfusion 和 POAG 的结构变化之间的关系是必不可少的.

研究的目的:

在POAG患者和健康个体中,比较和评估视网膜神经纤维层 (RNFL) 厚度,周包膜视网膜 perfusion 密度和流量指数之间的相关性.
调查血管变化在POAG病理生理学中的作用.

主要方法:

一项涉及POAG患者53只眼睛和56只健康眼睛的横截面研究.
使用光学连贯断层扫描血管学 (OCTA) 测量周周膜输液密度和流量指数.
使用Cirrus光连贯断层扫描 (OCT) 评估的RNFL厚度.

主要成果:

与健康对照组相比,POAG患者在大多数象限中表现出显著下降的周包膜视网膜 perfusion 密度和流量指数 (p=0.0001).
在所有象限的POAG患者中,RNFL厚度显著降低 (p≤0.017).
在POAG受试者中,在周包膜 perfusion 参数和RNFL厚度之间发现了中度到强烈的相关性.

结论:

降低周包膜 perfusion 密度和流量指数与POAG.中RNFL稀释显著相关.
在POAG.中观察到的结构变化中,周周血管变化起着作用.
将血管评估与结构成像相结合,可以提高POAG诊断和管理.

关键词:

流量指数是指流量指数.光学连贯性断层扫描血管图谱周 papillary 视网膜 perfusion 密度周 papillary 视网膜 perfusion 密度周 papillary 视网膜 perfusion 密度周 papillary 视网膜 perfusion 密度周 papillary 视网膜 perfusion 密度周 papillary 视网膜 perfusion 密度周 papillary 视网膜 perfusion 主要的开放角光眼.视网膜神经纤维层厚度视网膜神经纤维层厚度

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