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氧化铁纳米颗粒的生物合成及其抗微生物和生物相容性研究:一种可持续的方法

Rachana Yadwade¹, Peram Babu², Balaprasad Ankamwar¹

¹Bio-Inspired Materials Research Laboratory, Department of Chemistry, Savitribai Phule Pune University (Formerly University of Pune), Ganeshkhind, Pune, 411007 India.

|October 20, 2025

概括

磁性铁氧化物纳米粒子 (IONPs) 是使用 Acacia concinna 提取物合成的. 这些生物相容的IONP显示出药物输送和治疗应用的前景,尽管它们缺乏抗菌活性.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物技术是生物技术.

背景情况:

氧化铁纳米粒子 (IONPs) 在各种生物医学应用中至关重要.
绿色合成方法为纳米粒子生产提供了可持续的替代方案.
阿卡西亚孔西纳提取物含有生物分子,可以起到减少和稳定剂的作用.

研究的目的:

为了合成磁性氧化铁纳米颗粒 (IONPs),使用 Acacia concinna pod 提取物.
为了描述合成的IONP的形态,磁性和表面积.
评估IONP的抗菌活性和生物相容性.

主要方法:

使用 Acacia concinna pod 提取物作为生物降解剂和稳定剂合成 IONP.
使用野外发射扫描电子显微镜 (FESEM),振动样本磁力测量 (VSM),布鲁纳uer-Emmett-Teller (BET) 分析和X射线光电谱学 (XPS) 的表征.
对各种细菌和真菌进行抗菌活性测试.
对L929正常纤维细胞细胞系的细胞毒性评估.

主要成果:

不同类型的IONP形态 (球形和棒形) 具有特定的大小和尺寸比.
显著的和磁化 (54.284 欧元/g) 和表面积 (59.851 m2/g).
通过XPS证实了Fe2O3的形成,并确定了pentadecanoic酸在合成中的作用.
缺乏针对测试病原体的抗微生物活性.
在L929细胞上没有观察到细胞毒性的生物相容性.

结论:

阿卡西亚孔西纳提取物对磁性IONP的绿色合成有效.
合成的IONP是生物相容和非细胞毒性的.
这些IONP是药物输送,治疗和诊断应用的合适候选者.

关键词:

生物相容性生物相容性生物合成生物合成磁性氧化铁纳米材料磁性氧化铁纳米材料非抗微生物的非抗微生物药物

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