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末期肺病患者的肉类症:系统性审查和元分析
Li Sheng1, Peipei Gu1, Lingyun Cai1
1Department of Nursing, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, Hangzhou, China.
Frontiers in medicine
|October 20, 2025
概括
麻症或与年龄相关的肌肉损失,影响31.6%的末期肺部疾病患者. 患病率因年龄,性别,种族和肺部状况而异,影响结果.
科学领域:
- 老年学是指老年学的学科.
- 肺部病理学 肺部病理学
- 肌肉生理学 肌肉生理学
背景情况:
- 萨科佩尼亚是一种常见的与年龄相关的疾病.
- 它对末期肺部疾病 (ELD) 的患者产生重大影响,影响疾病进展和临床结果.
- 目前用于量化萨科佩尼亚的方法存在,但ELD患者的患病率需要全面评估.
研究的目的:
- 为了评估末期肺部疾病 (ELD) 患者中萨尔科佩尼亚的患病率.
- 探索影响ELD患者中萨尔科佩尼亚患病率的因素.
- 调查ELD中肉症的临床影响.
主要方法:
- 在多个英语数据库 (PubMed,WOS,Embase,Cochrane Library,CINAHL,Scopus) 进行了系统的文献搜索.
- 研究的质量是使用JBI分析跨部分研究的批判性评估清单来评估的.
- 使用Stata 18.0和R 4.4.3软件进行了元分析,用随机效应模型计算了聚合流行率,并进行了子组分析.
主要成果:
- 24项涉及6800名患者的横截面研究被纳入了分析.
- 在ELD患者中,肉类的综合患病率为31.6% (95%CI:26.5-36.8%).
- 在老年患者 (≥70岁),男性,亚洲人群,COPD患者以及使用AWGS2019标准或DXA进行评估时,观察到更高的患病率.
结论:
- 在末期肺部疾病患者中,肉类症的患病率很高,在不同的人口和临床亚组中存在显著差异.
- 诸如年龄,性别,种族,特定的肺病类型,诊断标准和评估方法等影响因素有助于患病率差异.
- 建议采取针对这些因素的有针对性的干预措施,以减轻肉症的发生率并改善患者的生活质量.
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