三甲糖-葡萄糖 (TyG) 指数与痴呆症之间的关系中的性别差异
Giovanni Zuliani1, Gloria Brombo1, Francesco di Paola Dario1
1Department of Translational Medicine and for Romagna, Università of Ferrara, Via Luigi Borsari 46, Ferrara, 44121 Italy.
Journal of diabetes and metabolic disorders
|October 20, 2025
概括
高胰岛素耐药性,通过三甘油-葡萄糖 (TyG) 指数测量,与老年妇女痴呆风险增加有关. 这种关联在轻度认知障碍和血管痴呆症中观察到,但不是阿尔茨海默病.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
背景情况:
- 胰岛素耐药性越来越被认为是导致认知能力下降的一个因素.
- 三甘油-葡萄糖 (TyG) 指数是评估胰岛素耐药性的验证标记.
- 了解性特异性痴呆风险因素对于有针对性的预防策略至关重要.
研究的目的:
- 调查三糖糖 (TyG) 指数与痴呆症之间的联系.
- 为了确定这种关联是否在老年人群中性别之间存在差异.
主要方法:
- 该研究包括来自意大利记忆诊所的1245名参与者,按认知状态分类:阿尔茨海默病,血管痴呆症,混合痴呆症,轻度认知障碍和健康对照.
- 所有参与者都计算了甘油三 - 葡萄糖 (TyG) 指数.
- 进行了统计分析,包括多调整模型,以评估TyG指数和认知状态之间的关系,按性别分层.
主要成果:
- 在女性中,高TyG指数与轻度认知障碍 (OR: 1.91),血管痴呆 (OR: 2.23) 和混合痴呆 (OR: 1.92) 的可能性增加显著相关.
- 在女性中,高TyG指数和阿尔茨海默病之间没有发现显著的关联 (OR:1.07).
- 在调整了年龄,吸烟,总胆固醇和并发症后,这些关联仍然很重要.
结论:
- 根据TyG指数显示的胰岛素耐药性可能是患有脑血管成分的痴呆症亚型的危险因素.
- 这些发现突出了潜在的性别特异性脆弱性,表明年龄较大的女性可能更容易受到胰岛素抵抗的认知影响.
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