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SARS-CoV-2 帕帕因类蛋白酶抑制剂 基于纳夫他林-1-乙乙胺和化二基组分类

Kouki Shinohara1, Takuya Kobayakawa1, Kohei Tsuji1

  • 1Department of Medicinal Chemistry, Laboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo, Chiyoda-ku, Tokyo 101-0062, Japan.

ACS omega
|October 20, 2025
PubMed
概括

研究人员开发了针对SARS-CoV-2类似帕帕因蛋白酶 (PLpro) 的新型抑制剂. 来自GRL-0048的化合物9r显示出对这一关键病毒酶的显著增强的抑制活性.

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