开发低粘度滑剂,以保持超管和肠镜之间的滑性,以提高单气球肠镜检查期间的机动性
Katsuma Yamauchi1,2, Ryohei Hirose1,2, Taku Kanou1,2
1Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
ACS omega
|October 20, 2025
概括
新的滑剂显著减少了肠镜检查期间的摩擦,改善了内镜操作. 这些剂比水更好地保持低动态摩擦系数 (DFC),解决插入阻力和增强程序.
科学领域:
- 胃肠病学 胃肠病学
- 生物材料科学 生物材料科学
- 医疗设备工程 医疗设备工程
背景情况:
- 肠镜术依赖于水友性涂层,以使内镜轴 (ES) 在上管 (OT) 中顺利插入.
- 在长时间的处理过程中,这些涂料的降解会增加动态摩擦系数 (DFC),导致插入阻力和操作不良.
- 标准用纯水滑的有效性随着时间的推移而减弱.
研究的目的:
- 为了研究水友性涂层的降解和随之而来的DFC在肠镜检查期间的增加.
- 开发和验证一种模型,用于在ES和OT之间连续测量DFC.
- 与纯水相比,确定最优的滑剂,保持较低的DFC并改善内镜操纵.
主要方法:
- 开发了一种独特的模型,在模拟肠镜检查过程中连续测量DFC30分钟.
- 在模拟条件下测试纯水和各种滑剂溶液 (碳甲基纤维素,甲基酸盐,乙基纤维素,香).
- 测量了每个测试物质的初始DFC,30分钟后的DFC和DFC增加率.
主要成果:
- 纯水滑显示了0.112的初始DFC,在30分钟后增加了219%至0.357.
- 碳氧甲基纤维素,酸,基甲基纤维素和香甘的初始DFC显著较低 (分别为0.073,0.081,0.079和0.063).
- 这些最佳滑剂在30分钟内保持低DFC,增幅最小 (+2.5%, -0.2%, -5.9%, +5.6%),并且需要低注射压.
结论:
- 水友性涂层降解在肠镜检查期间显著增加DFC,影响机动性.
- 与纯水相比,特定的滑剂溶液 (例如,桑坦,藻酸盐) 提供了优越和持续的滑.
- 这些已识别的最佳滑剂有可能提高内镜操作和肠镜检查期间患者的结果.
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