基于l-氨酸的电化学传感器在药品中用于测定氨酸的分析应用
Maria Eduarda C Goulart1, Lucas D Paquini2, Luciene P R Profeti3
1Department of Pharmacy and Nutrition, Federal University of Espírito Santo-UFES, 29500-000 Alegre, ES, Brazil.
ACS omega
|October 20, 2025
概括
在玻璃碳电极 (GCE) 上使用电聚化l-氨酸的新型电化学传感器被开发用于在药片中敏感的氨酸测定. 这种传感器提供了一种可靠的方法,用于在药品样本中量化奎蒂亚平.
科学领域:
- 电化学 电化学 电化学
- 材料科学 材料科学 材料科学
- 分析化学 分析化学
背景情况:
- 奎蒂亚平是一种非典型的抗精神病药物.
- 在药物配方中精确量化奎蒂亚平对于治疗疗效和患者安全至关重要.
- 药物分析需要开发敏感和选择性的电化学传感器.
研究的目的:
- 开发和表征一种用于测定氨酸的电化学传感器.
- 通过使用拟议的传感器,研究奎蒂亚平的电化学行为.
- 评估传感器在药品片中测量奎蒂阿平的适用性.
主要方法:
- 在玻璃碳电极 (GCE) 上对l-氨酸的电聚合.
- 使用电化学阻抗光谱学 (EIS) 进行电化学表征.
- 使用方波电压计 (SWV) 和循环电压计 (CV) 量化奎蒂亚平的量化.
主要成果:
- 聚- ((l-cys) /GCE传感器显示了对提氨酸氧化过程的电催化活性.
- 在quetiapine度范围8.0585.0μmol L-1中观察到线性,低检测极限为1.17μmol L-1.1.
- 该传感器在药品片样中选择性定量提氨酸时显示出成功的适用性.
结论:
- 开发的poly- ((l-cys) /GCE电化学传感器对于敏感和选择性测定奎胺是有效的.
- 这种传感器提供了一种可行的分析工具,用于药物配方中的奎蒂亚平的质量控制.
- 该研究强调了电聚合氨基酸在开发用于药物分析的电化学传感器方面的潜力.
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