建平伟颗粒用于化疗诱导的胃肠道反应:一项随机双盲,安慰剂控制的随机试验
Kerun Cai1, Jiayang Chen2, Nuo Li1
1Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Anti-cancer agents in medicinal chemistry
|October 20, 2025
概括
传统中医药Jianpi Yiwei颗粒 (JPYW) 在非小细胞肺癌患者中有效降低了化疗引起的消化问题,如恶心和厌食症. 这种治疗改善了生活质量,并与标准抗药物一起证明了安全性.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 传统中国医药 传统中国医药
背景情况:
- 化疗诱导的胃肠道反应在接受基于卡博普拉丁的治疗方案的非小细胞肺癌 (NSCLC) 患者中很普遍.
- 传统中医药 (TCM) 配方Jianpi Yiwei颗粒 (JPYW) 显示出减轻这些不良影响的潜力.
- 现有研究表明,某些中国草药,如生,在治疗化疗引起的恶心和吐 (CINV) 中具有有效性.
研究的目的:
- 评估JPYW在缓解非吐性消化系统症状 (包括恶心和厌食症) 的有效性,在接受基于碳烯的化疗的NSCLC患者中.
- 评估JPYW对改善其他胃肠道症状,如胀气和便秘的影响.
- 确定JPYW对该患者群体生活质量和安全概况的影响.
主要方法:
- 进行了一项多中心,随机,双盲,安慰剂控制的试验,涉及136名NSCLC患者.
- 参与者被随机分配,接受JPYW与标准抗药物或安慰剂与标准抗药物.
- 效率是通过恶心和吐的完全控制率 (视觉模拟量表,患者日记) 和使用功能性生活指数-Emesis量表和简要疲劳清单 (BFI) 的其他症状来衡量.
主要成果:
- 该研究主要评估了JPYW在减少恶心和厌食症方面的有效性.
- 二次结果包括胀气,便秘和整体生活质量的改善.
- 在与标准化疗同时使用时,JPYW的安全性也得到了评估.
结论:
- 含有来自Codonopsis pilosula和Atractylodes macrocephala的活性化合物的JPYW在治疗化疗引起的消化症状方面表现出潜力.
- 配方的抗炎和发动性作用可以协同调节胃肠功能.
- 初步发现表明,JPYW与标准化疗一起使用是安全的,有助于改善患者的生活质量.
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