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美国成年人中饮食中的铜摄入量和生物衰老,NHANES 2003-2018年
Liujie Zheng1, Guoqiang Li1, Jingcheng Cao1
1Department of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, China.
Aging cell
|October 20, 2025
概括
饮食中较高的铜摄入量与较慢的生物衰老有关,减少了表型年龄及其加速. 饮食炎症指数部分介导这种保护作用.
科学领域:
- 营养科学 营养科学
- 老年学是指老年学的学科.
- 生物统计学 生物统计学
背景情况:
- 饮食中的铜对健康的影响是众所周知的,但其与生物衰老的联系仍然未被探索.
- 生物衰老标志物如表型年龄 (PhenoAge) 和表型年龄加速 (PhenoAgeAccel) 对于健康跨度研究至关重要.
- 饮食炎症指数 (DII) 可能会影响衰老过程,并调解营养与饮食模式的关系.
研究的目的:
- 调查饮食中的铜摄入量与生物衰老标志物 (PhenoAge,PhenoAgeAccel) 之间的关联.
- 检查饮食炎症指数 (DII) 在这种关系中的潜在调解作用.
- 分析剂量反应模式和非线性关联,使用受限立方线.
主要方法:
- 从国家健康和营养检查调查 (NHANES) (2003-2018) 中对18160名成年人的横截面分析.
- 使用了加权多变量线性回归,子组分析和趋势测试.
- 限制立方线 (RCS) 模型评估了非线性关系;调解分析探索了DII的作用.
主要成果:
- 饮食中的铜摄入量与生物衰老有显著的负面关联.
- 铜摄入量的每个单位增加与PhenoAge的1.12年下降和PhenoAgeAccel的1.45年下降相关.
- 观察到一种非线性反向关系,在较低的铜摄入量时效果更强烈;DII调解了这种关联.
结论:
- 增加饮食中的铜摄入量与减少生物衰老有关.
- 促进饮食中更高的铜消费的公共卫生倡议可以缓解生物衰老.
- 这些发现强调了铜在健康老龄化中的潜在作用,其中DII作为一个贡献因素.
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