患有阻塞性睡眠呼吸暂停的成年人中认知障碍的患病率:系统性审查和元分析
Kailin Su1,2,3, Zhenzhen Feng4,5,6, Lu Wang1,2,3
1Department of Respiratory Diseases, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450003, China.
Sleep & breathing = Schlaf & Atmung
|October 20, 2025
概括
认知障碍影响了近37%的成年人患有阻塞性睡眠呼吸暂停 (OSA). 这种患病率强调迫切需要采取公共卫生举措,并进一步研究OSA患者的有效管理策略.
科学领域:
- 神经学 神经学
- 公共卫生 公共卫生
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 越来越被认为是一个重大的公共卫生问题.
- 与OSA相关的认知障碍对患者福祉和医疗保健系统构成越来越大的挑战.
研究的目的:
- 系统地审查和对现有文献进行元分析.
- 估计被诊断患有阻塞性睡眠呼吸暂停的成年人认知障碍的综合患病率.
主要方法:
- 在主要数据库 (PubMed,Embase,Cochrane Library,Web of Science) 进行全面的文献搜索,截至2025年2月2日.
- 包括正式诊断的OSA和验证的认知评估的研究.
- 使用Stata 17.0进行的元分析,并评估了出版偏差.
主要成果:
- 在23项研究中,在33226名患有OSA的成年人中,发现认知障碍的综合患病率为36.92%.
- 患病率因OSA的严重程度,诊断方法 (PSG与HSAT),认知评估工具 (MoCA,MMSE,CDR,CFF) 和地理区域而异.
- 在严重的OSA,使用多睡眠学研究以及东南亚等特定地区观察到更高的患病率.
结论:
- 在OSA患者中认知障碍的大量流行需要更多的公共卫生关注.
- 采用标准化协议的进一步跨国纵向研究对于开发基于证据的管理策略至关重要.
相关概念视频
Sleep Apnea
475
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
475
Substance Use Disorders Affecting Sleep
398
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
398
Insufficient Sleep and Sleep Deprivation
828
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
828
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.1K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.1K
Cognitive Development During Adulthood
770
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
770
Management of Insomnia
528
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
528


