儿科FMF肝功能变化:探索疾病动态和治疗影响
Büşra Başer Taşkın1, Ayşenur Doğru Kılınç1, Selen Duygu Arık1
1Division of Pediatric Rheumatology, Department of Pediatrics, Faculty of Medicine, Istanbul University, Istanbul, 34093, Turkey.
European journal of pediatrics
|October 20, 2025
概括
对于儿童的家族地中海热 (FMF) 进行素治疗通常会导致轻度,暂时的肝功能测试升高. 这些肝酶变化通常是可控的,这表明菌素是可控的.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 自燃性炎症疾病 自燃性炎症疾病
- 肝病学 肝病学是一种肝病学.
背景情况:
- 家庭地中海热 (FMF) 是最常见的自身炎症性疾病,用菌素治疗.
- 科尔奇辛虽然有效,但具有狭窄的治疗指数和潜在的不良影响,包括肝毒性.
- 监测肝功能对于长期接受素治疗的儿科FMF患者至关重要.
研究的目的:
- 评估胆固醇对患有 FMF 的儿童肝功能测试 (LFT) 的影响.
- 在这个队列中调查LFT升高的潜在原因.
- 为了监测胆固醇治疗期间肝酶异常的临床过程.
主要方法:
- 在开始使用胆固醇药后≥2周,儿科FMF患者的LFT升高的回顾性分析.
- 数据收集包括人口统计,临床特征,MEFV变体,疾病严重程度,素剂量和并发症.
- 对LFT升高进行了分类,并对患者进行了正常化或持续异常的跟踪.
主要成果:
- 大多数LFT升高 (94.4%) 是轻微的,74%的患者在一个月内恢复正常.
- 经过平均46.5个月的素治疗后,出现了LFT异常.
- 肝硬化和肥胖症在患有复发性/持续性LFT升高的患者中更常见.
结论:
- 儿科FMF中与胆固醇相关的LFT升高通常是轻微的,短暂的和可控的.
- 在这种人群中,黄素对肝脏似乎是安全的,但建议进行持续监测.
- 进一步的长期研究是有必要的,以充分了解安全性.
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