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儿科B细胞淋巴细胞急性白血病中频繁的TCR重组:基因组和表型特征

Jiajia Zheng¹, Yiting Wang^2,3, Zhiheng Li⁴

¹Department of Hematology & Oncology, Children's Hospital of Soochow University, Suzhou, 215000, China.

Annals of hematology

|October 20, 2025

概括

T细胞受体 (TCR) 融合在儿科B型急性淋巴细胞白血病 (B-ALL) 中出乎意料地频繁. 这些融合表明干细胞起源,并与更高的风险和最小的残留疾病有关.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
遗传学是一个遗传学.

背景情况:

T细胞受体 (TCR) 基因重组对T细胞发育至关重要.
在V(D) J重组中的错误可能导致瘤基因激活和T细胞急性淋巴细胞白血病 (T-ALL).

研究的目的:

调查TCR融合在儿科B型急性淋巴细胞白血病 (B-ALL) 的患病率和影响.

主要方法:

根据世卫组织标准诊断的97例儿科B-ALL病例的回顾性分析.
识别TCR融合和相关的基因组改变.
对基因表达特征和临床结果的分析.

主要成果:

一个B-ALL病例的子组与各种伙伴基因 (例如,LINC01656,TCL1A/B,CDKN2A) 存在TCR融合.
具有TCR融合阳性B-ALL的基因表达丰富于造血干细胞 (HSC) 签名.
患有TCR融合的患者患病风险增加和较高的最小残留疾病 (MRD).

结论:

在B-ALL中,TCR融合是常见的,表明潜在的干细胞衍生的白血病.
这些发现表明可能存在双重B细胞和T细胞谱系分化能力.
基于MRD的风险导向治疗可能有利于TCR重组的B-ALL.患者.

关键词:

B细胞急性淋巴细胞白血病.儿科儿科儿科在TCR的核聚变过程中,

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