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Updated: Jan 14, 2026

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使用单链LNA/MOE混合器和仿真Invader:XenoRNA探针进行高效和特定的DNA向

Michaela E Everly1, Patrick J Hrdlicka1

  • 1Department of Chemistry, University of Idaho, Moscow, Idaho 83844-2343, USA. hrdlicka@uidaho.edu.

Organic & biomolecular chemistry
|October 20, 2025
PubMed
概括

交叉器功能化的寡核酸与Xeno RNAs形成异重复,使得有效的DNA目标入侵成为可能. 这些DNA准探针对双链DNA具有异常的结合特异性.

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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
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