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对有毒元素的综合网络分析共同暴露和由氧化应激/炎症引发的病理生理变化在城市卫生工作者中

Maryam Mansouri¹, Sima Afrashteh², Akram Farhadi³

¹Department of Environmental Health Engineering, Faculty of Health and Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran.

Biological trace element research

|October 20, 2025

概括

暴露在潜在有毒元素 (PTEs) 的城市卫生工作者显示出血液生物标志物的显著变化. 网络分析显示,和是影响健康的关键PTE,突出了公共卫生问题.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
生物医学科学生物医学科学

背景情况:

城市卫生工作者面临着对潜在有毒元素 (PTEs) 的职业暴露.
了解PTE对这一群体的病理生理影响对于公共卫生至关重要.
网络分析提供了一种新的方法来可视化PTE和生物标记物之间的复杂相互作用.

研究的目的:

为了调查PTE暴露导致的城市卫生工作者的病理生理变化.
通过网络分析识别关键的PTE及其与生物标志物的相互作用.
评估PTE暴露在这个职业群体中的公共卫生影响.

主要方法:

与暴露组 (城市卫生工作者) 和对照组 (管理人员) 进行比较研究设计.
使用感应合血质谱法 (ICP-MS) 量化血清中PTE水平.
使用Cytoscape软件进行网络分析和可视化,绘制PTE-生物标志物相互作用的地图.

主要成果:

暴露组和对照组之间血液指数 (WBC,RBC,HB,MCHC,淋巴细胞,乙酸氨基) 的统计学上显著差异 (p < 0.001).
(As), (Cd) 和 (Pb) 被确定为最有影响力的PTE.
氧化应激/炎症标志物 (8-OHdG,TNF-α) 介导PTE对肝功能 (ALT,AST) 和其他系统的影响.

结论:

固体废物收集器中PTE暴露的增加是一个严重的公共卫生问题.
网络分析有效地可视化了PTE和不良健康结果之间的复杂相互作用.
包括工程控制,个人防护设备,健康监测和政策执行在内的全面战略对于工人保护至关重要.

关键词:

生物监测生物监测网络分析网络分析职业暴露职业暴露有毒金属有毒金属城市卫生工作者

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