在0.45%的正常盐溶液和血LyteA中,埃尔塔烯和梅罗烯的物理兼容性
Berah Brown1, Jacquelyn Schemmel1, Justin P Reinert2
1University of Toledo College of Pharmacy and Pharmaceutical Sciences, Toledo, Ohio.
International journal of pharmaceutical compounding
|October 20, 2025
概括
埃尔塔佩内姆与0.45%的化和Plasma-Lyte A物理兼容. 埃尔塔佩内姆在这些液体中表现出超过8小时的10毫克/毫升和5小时的20毫克/毫升度的物理不兼容性.
科学领域:
- 制药科学 制药科学
- 临床药房 临床药房
- 静脉输液兼容性研究 静脉输液兼容性研究
背景情况:
- 患者的安全性和最佳的临床结果取决于静脉注射药物和液体的物理兼容性.
- 在0.45%的化和Plasma-Lyte A中,埃尔塔烯和美罗烯的物理兼容性尚未最终确定.
- 了解药物-液体兼容性对于安全的静脉注射药物管理至关重要.
研究的目的:
- 为了评估0.45%化和Plasma-Lyte A.中的ertapenem和meropenem的体外物理兼容性.
- 在特定度下,在24小时内确定埃尔塔烯和美罗烯混合物的稳定性.
- 提供支持这些抗生素安全Y-site管理的数据.
主要方法:
- 在体外分析10毫克/毫升和20毫克/毫升的埃尔塔因和美罗因的物理兼容性.
- 在24小时内用0.45%的化和Plasma-Lyte A进行了测试.
- 混合物被视觉检查,并在多个时间点进行光谱光度和pH分析.
主要成果:
- 埃尔塔胺添加剂在24小时内在两种液体中表现出物理兼容性.
- 在0.45%化和Plasma-Lyte A.两种药物中,Meropenem 10 mg/mL在8小时以后显示出物理不相容性.
- 梅罗 20 mg/mL 在0.45%的化中超过5小时是身体不相容的.
结论:
- 埃尔塔胺10 mg/mL和20 mg/mL在物理上与0.45%的化和Plasma-Lyte A.相容.
- 梅罗胺的兼容性取决于度和液体,在5-8小时以后观察到限制.
- 建议进行进一步的化学稳定性研究,以补充这些物理兼容性发现.
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