甲酸与0.45%的化,乳酸林格溶液和等离子-莱特A的物理兼容性
Chinenye G Ezema1, Mitchell S Howard1, Gabriella Baki1
1University of Toledo College of Pharmacy and Pharmaceutical Sciences, Toledo, Ohio.
International journal of pharmaceutical compounding
|October 20, 2025
概括
在24小时内与0.45%的化相容. 然而,由于pH值的显著变化,它在一小时后与乳酸林格和Plasma-Lyte A表现出物理不相容.
科学领域:
- 制药科学 制药科学
- 临床药房 临床药房
- 药物兼容性研究 药物兼容性研究
背景情况:
- 有限的数据存在于 orphenadrine 酸盐与常见静脉注射液体的物理兼容性.
- 之前的报道仅记录了与0.9%的化与二甲结合的兼容性.
研究的目的:
- 为了评估与0.45%的化 (0.45%NaCl),乳酸林格斯 (LR) 和等离子-莱特A (PLA) 混合时的酸的物理兼容性.
主要方法:
- 甲酸与每个研究液体的三倍混合,度为0.24,0.6和1.2 mg/mL.
- 物理兼容性通过视觉检查,光谱吸光度和pH分析在指定的时间点 (0,1,5,8和24小时) 评估.
主要成果:
- 在任何样本中都没有观察到视觉或光谱变化.
- 在0.45%NaCl中,pH保持稳定24小时,在LR (0.24 mg/mL) 中保持稳定1小时.
- 与基线相比,所有Plasma-Lyte A样本在1小时后都发现了显著的pH变化 (>0.1单位).
结论:
- 甲酸表明与0.45%NaCl的物理兼容性长达24小时.
- 乳酸林格和血-莱特A被认为与1小时以上的甲酸不相容.
- 建议对化学稳定性进行进一步的研究,以证实这些物理兼容性发现.
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