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Updated: Jun 25, 2026

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
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符合ARRIVE 2.0:对动物模型中毒治疗疗效测试的报告要点

Amy E Marriott1, Stuart Ainsworth1

  • 1Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L3 5RF, United Kingdom.

Toxicon : official journal of the International Society on Toxinology
|October 20, 2025
PubMed
概括

临床前抗毒研究报告准则提高了可重复性. 一个新的框架提高了毒素中和试验的透明度,促进了更好的科学和动物福利.

关键词:
抗毒剂是一种抗毒剂.在生物体内,在生物体内.鼠类模型的模型.临床前 临床前这是Venom的毒药.

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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...