相关实验视频

Updated: Jan 14, 2026

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

在糖尿病老鼠中,Naofucong通过"能量代谢-基因组激素乳化修饰"途径改善了认知功能

Ruiying Yin¹, Yue Tian¹, Mei Ma¹

¹Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China.

Free radical biology & medicine

|October 20, 2025

概括

纳福康 (NFC) 通过改善大脑能量代谢和改变基因素乳化来增强糖尿病大鼠的认知功能. 这项研究揭示了治疗糖尿病认知障碍 (DCI) 的新机制.

科学领域:

神经科学是一个神经科学.
代谢障碍代谢障碍代谢障碍
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

糖尿病认知障碍 (DCI) 与大脑能量代谢中断有关.
乳酸在神经功能中扮演着双重角色,作为代谢物和表观遗传调节剂.
了解乳酸的影响是解决DCI的关键.

研究的目的:

为了调查Naofucong (NFC) 是否可以改善糖尿病老鼠的DCI.
为了探索NFC对海马体能量代谢和基因素乳酸化的影响.
阐明NFC治疗潜力的基础分子机制.

主要方法:

已建立的糖尿病大鼠模型 (n=60) 与对照,糖尿病,NFC和氧酸盐组.
使用行为测试评估认知功能.
通过空间代谢学分析海马的代谢功能.
使用CUT&Tag测序和Westernblotting进行机械洞察.

主要成果:

在糖尿病大鼠中,NFC治疗显著改善了认知功能.
NFC增强了海马体的能量代谢,并增加了谷氨水平.
通过NFC调节的基因素乳化,影响基因素受体H4 (Hrh4) 表达.

结论:

通过恢复大脑能量平衡,NFC证明了DCI的治疗潜力.
改变基因素乳化是NFC作用的关键机制.
这项研究为DCI治疗提供了一个新的治疗点.

关键词:

糖尿病认知障碍糖尿病认知障碍能量代谢能量代谢基因素乳酸化修改的基因素乳酸化修改空间代谢学空间代谢学

更多相关视频

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

相关概念视频

Pathophysiology of Diabetes

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...

Hormones Regulating Blood Glucose

Hormones Regulating Blood Glucose

Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...