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身体组成和相角作为急性淋巴细胞白血病成年人的预后因素
Víctor Itaí Urbalejo Ceniceros1, Omar Eduardo Fernandez Vargas2, Erendira Baltazar Luna3
1Department of Hematology, Instituto Nacional de Cancerología, Mexico City, Mexico.
阶段角 (PhA) 和无脂肪质量指数 (FFMI) 是成人急性淋巴细胞白血病 (ALL) 的关键预后标志物. 较低的PhA和降低的FFMI表明生存率较差,突出显示了ALL患者早期营养评估的必要性.
科学领域:
- 在瘤学瘤学.
- 临床营养学 临床营养学
- 生物统计学 生物统计学
背景情况:
- 在成人急性淋巴细胞白血病 (ALL) 中,身体组成和相角 (PhA) 的预后意义尚未得到充分确立.
- 这项研究研究了身体组成参数和PhA对接受密集化疗的ALL患者的生存结果的影响.
研究的目的:
- 评估成人ALL患者体质组成和PhA的预后作用.
- 确定PhA,无脂肪质量指数 (FFMI) 和整体存活率 (OS) 和无疾病存活率 (DFS) 之间的关联.
主要方法:
- 对81名成年ALL患者的回顾性分析.
- 生物电阻分析 (BIA) 用于基线身体组成评估 (包括PhA,FFMI).
- 卡普兰-梅尔,日志等级测试和多变量考克斯回归分析用于生存结果评估.
主要成果:
- 较低的PhA (≤4°) 和FFMI (<16 kg/m2) 与较差的OS显著相关 (分别为p=0.02和p=0.0163).
- 多变量分析确定了PhA≤4°,低albuminemia和非常高风险的细胞遗传学作为更糟糕的OS的独立预测因素.
- 身体质量指数 (BMI) ≥25显示出更糟糕的生存状况趋势,但没有统计学意义.
结论:
- 阶段角 (PhA) 和无脂肪质量指数 (FFMI) 是成人ALL的宝贵预后标志物.
- 降低PhA和FFMI与较差的生存结果相关.
- 建议对ALL患者进行早期营养评估和干预策略.
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