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来自艾滋病毒感染者捐赠者的潜在心胸器官池

Mary G Bowring¹, Jessica M Ruck¹, Zeba Nauroz¹

¹Johns Hopkins University School of Medicine, Baltimore, MD.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

|October 20, 2025

概括

从艾滋病毒阳性捐赠者扩大器官捐赠,包括心脏和肺部移植,可以显著增加艾滋病毒阳性接受者的救命心胸器官的可用性. 这项研究强调了根据艾滋病毒器官政策公平 (HOPE) 法案增加心脏和肺移植的潜力.

科学领域:

移植免疫学移植免疫学
传染病研究传染病研究.
公共卫生政策公共卫生政策

背景情况:

艾滋病毒器官政策公平法案 (HOPE) 最初限制了艾滋病毒阳性到艾滋病毒阳性 (HIV D + / R +) 移植和肝脏.
最近的指导方针修改允许更广泛的心胸计划参与HIV D+/R+移植.

研究的目的:

估计艾滋病毒感染者中潜在心胸器官捐献者的数量.
评估扩大艾滋病毒D+/R+移植的可行性,包括心脏和肺部器官.

主要方法:

从2016年3月到2024年12月使用的移植受体科学注册表 (SRTR) 数据.
开发了一个后勤回归模型来预测基于无艾滋病毒捐赠者的/肝捐赠的心胸捐赠概率.
应用该模型来估计在现有HIV器官政策公平法案 (HOPE) 捐赠者中潜在的心胸器官捐赠者.

主要成果:

估计41.0%的HOPE捐赠者是潜在的心脏捐赠者,18.7%是潜在的肺部捐赠者.
这可以翻译为每年13-18个心脏和5-8个肺移植来自HOPE捐赠者.
在没有艾滋病毒的捐赠者中,心胸捐赠与年龄,死亡原因以及高血压和糖尿病等并发症等因素有关.

结论:

将HIV D+/R+移植扩展到心胸器官可以利用现有的HOPE捐赠者的很大一部分.
大约41%的HOPE脏和肝脏捐赠者可能会捐献心脏,近20%的人可能会捐献肺.
这种扩张为等待心脏或肺部移植的HIV阳性候选人增加器官供应提供了一个有希望的途径.

关键词:

心胸捐赠者的心脏.进行心胸移植.艾滋病毒移植到艾滋病毒移植 "希望法案"就是希望法案.器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器

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