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一个基于可穿戴的老龄化时钟与疾病和行为有关

Andrew C Miller¹, Joseph Futoma², Salar Abbaspourazad²

¹Apple Inc., Cupertino, CA, USA. acmiller@apple.com.

Nature communications

|October 20, 2025

概括

穿戴式传感器现在可以使用光聚聚光学 (PPG) 来估计生物年龄. 这个PpgAge时钟可以预测时间的年龄,并识别心脏病和糖尿病风险较高的人.

科学领域:

衰老的生物标志物
长寿研究的研究.
数字健康数字健康

背景情况:

衰老的时钟对于理解寿命和改善临床干预至关重要.
目前的衰老时钟依赖于临床数据 (血液,生命体征,成像).
可穿戴设备提供频繁,低成本,现实世界的测量.

研究的目的:

开发和验证PpgAge,这是一款使用消费者可穿戴设备的基于手腕的光电显微镜 (PPG) 的新型衰老时钟.
评估PpgAge在预测时间年龄方面的准确性及其与健康衰老指标的关联.

主要方法:

使用从一项大型观察研究 (果心脏和运动研究,n=213,593) 的PPG数据开发PpgAge.
对PpgAge差距 (预测年龄 - 时间表年龄) 与健康结果和行为相关的分析.
对PpgAge变化的纵向评估.

主要成果:

PpgAge准确地预测了时间的年龄,并反映了健康的衰老.
增加的PpgAge差距与心脏病,心力衰竭和糖尿病的诊断增加有关.
PpgAge差距预测了发生的心脏病事件,即使在控制了风险因素之后.
PpgAge与生活方式行为 (吸烟,运动,睡眠) 有关.
在怀孕期间和心脏事件时,PpgAge会急剧增加.

结论:

PpgAge是一种非侵入性,被动收集的衰老时钟,具有显著的临床潜力.
基于手腕的PPG衰老时钟可以识别患慢性疾病风险较高的人.
PpgAge提供了一个新的工具,用于使用可穿戴技术监测健康和衰老轨迹.

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