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Updated: Jan 14, 2026

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
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一个泛免疫疗法签名来预测内CD8+T细胞扩张

Munetomo Takahashi1,2, Mikiya Tsunoda3, Hiroyasu Aoki4,3,5

  • 1Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge, CB2 1QR, UK. munetomo.takahashi@gmail.com.

Nature communications
|October 20, 2025
PubMed
概括

研究人员开发了一种小鼠模型来追踪瘤中的CD8+T细胞克隆. 他们确定了T细胞扩张和对癌症免疫治疗的反应的预测特征,这对于治疗监测和开发至关重要.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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