早期蛋白质限制对脂肪组织发育的代际影响,由绵羊转录基因分析揭示
M Alonso-García1, A Suárez-Vega1, P A S Fonseca1,2
1Departamento de Producción Animal, Facultad de Veterinaria, Universidad de León, León, Spain.
Scientific reports
|October 20, 2025
概括
雌羊的母体营养蛋白质限制 (NPR) 影响后代的脂肪组织发育. 来自受限母亲的后代表现出增强的脂肪生成,影响脂肪沉积和牲畜管理.
科学领域:
- 动物科学动物科学
- 基因组学就是基因组学.
- 代谢研究研究 代谢研究
背景情况:
- 脂肪组织对于能量平衡至关重要.
- 母亲的饮食可以影响后代的新陈代谢和脂肪沉积.
- 营养蛋白质限制 (NPR) 是一种饮食干预,具有潜在的代际影响.
研究的目的:
- 为了研究母性NPR在青春期前雌羊对其后代的脂肪组织转录组的影响.
- 为了确定与脂肪沉积和母体蛋白质限制相关的基因.
- 了解早期的脂肪生成分子机制受到母亲营养的影响.
主要方法:
- 来自出生为对照羊羔和受蛋白质限制的母羊的周围脂肪的RNA测序 (RNA-Seq).
- 差异基因表达分析以识别核心-DEGs (脂肪沉积) 和MNPR-响应的DEGs (母体限制).
- 已识别的基因组的功能丰富分析.
主要成果:
- 羊羔的脂肪沉积与脂肪组织发育阶段相关:血管化 (高脂肪) 和脂肪生成 (低脂肪).
- 孕产妇的NPR促进了产后脂肪生成,并增强了后代的脂肪生成潜力,无论其肥胖程度如何.
- 确定了219个核心-DEG和215个MNPR响应的DEG,提供了转录基因洞察力.
结论:
- 在青春期前,母亲的营养蛋白质限制对后代的脂肪组织发育有持久的影响.
- 这项研究提供了转录学证据,证明母亲饮食对脂肪生成的代际影响.
- 这些发现对畜牧业生产和潜在的人类代谢健康有影响.
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