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战略性脂质纳米颗粒设计决定了视网膜输送后的内部限制膜破坏

Kaat De Clerck1, Emma De Coster1, Luca Paoletti1

  • 1Lab of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.

Drug delivery and translational research
|October 20, 2025
PubMed
概括

脂质纳米粒子 (LNP) 将mRNA输送到视网膜是具有挑战性的,这是由于内部限制膜 (ILM). 优化LNP设计,包括脂质选择和PEGylation,在ILM中断后增强视网膜细胞传染.

关键词:
原酶是一种原酶.内部限制膜膜的内部限制膜.静脉内注射 静脉内注射这是一个MRNA和MRNA.药物输送到视网膜中的药物.

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