双胞胎贫血多细胞血症序列中不良周产期结果的预测因素:来自单中心队列研究的证据
Keren Zloto1,2, Noa Rosenthal2, Stav Cohen2
1Department of Obstetrics and Gynecology, Fetal Medicine Unit, Sheba Medical Center, Ramat Gan, Israel.
Prenatal diagnosis
|October 20, 2025
概括
双胞胎贫血多细胞血症序列 (TAPS) 的早期诊断在单胞胎怀孕中与更糟糕的围产期结果相关. 这包括较低的生存率和较高的中枢神经系统 (CNS) 损伤发病率.
科学领域:
- 周围生理学 周围生理学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 新生儿科学 新生儿科学
背景情况:
- 双胞胎贫血多细胞血症序列 (TAPS) 是单胞胎怀孕的一个并发症.
- 了解TAPS对围产期结果的影响对于临床管理至关重要.
研究的目的:
- 为了评估TAPS怀孕中的围产期结果.
- 为了确定TAPS中不良结果的预后因素.
主要方法:
- 在第三级中心对32个TAPS病例 (2012-2024) 的回顾性分析.
- 保守治疗和干预措施 (输血,激光,胎儿杀死) 之间的结果比较.
- 基于妊娠年龄,中枢神经系统发现和生存状态的TAPS特征分析.
主要成果:
- 86%的产周生存率;双重,单一和没有生存率分别为78.1%,15.6%和6.2%.
- 干预组的早期诊断 (25 vs. 27 周) 和分娩 (30.6 vs. 32.6 周).
- 早期的TAPS诊断 (21 vs. 27周) 与单次/无存活和中枢神经系统异常 (25%) 有关.
结论:
- 早期的TAPS诊断与较差的围产期结局有关.
- 降低生存率和增加脑损伤风险与早期TAPS诊断有关.
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