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布忠益奇调节了T17细胞在自身免疫性甲状腺炎中通过PTEN/AKT-免疫代谢轴的分化

Jia-Yun Li¹, Zhuo Zhao¹, Dong-Lin Liu¹

¹Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110847, China.

Endocrine, metabolic & immune disorders drug targets

|October 21, 2025

概括

布雄基 (BZYQ) 通过调节通过PTEN/AKT-免疫代谢途径的Th17细胞分化,有效治疗自身免疫性甲状腺炎 (AIT),减少甲状腺损伤和自身抗体.

科学领域:

免疫学免疫学免疫学
内分泌学在内分泌学.
药理学药理学是指药理学的学科.

背景情况:

自身免疫性甲状腺炎 (AIT) 是一种常见的自身免疫性疾病,可导致甲状腺功能低下和降低生活质量.
了解AIT的分子机制对于开发有效的治疗策略至关重要.

研究的目的:

在诱导的自身免疫甲状腺炎 (AIT) 的小鼠模型中评估Buzhong Yiqi Decoction (BZYQ) 的治疗疗效.
阐明BZYQ在AIT中的作用的潜在分子机制,重点关注免疫代谢途径.

主要方法:

在NOD.H-2h4小鼠中使用化诱导了自身免疫性甲状腺炎.
通过检查甲状腺组织病理学,血清自身抗体 (TGAb,TPOAb) 和乳酸水平来评估治疗效果.
在PI3K/AKT路径和糖解中的关键分子 (PTEN,p-PI3K/PI3K,p-AKT/AKT,GLUT1,HK2,PKM2,LDHA) 的蛋白质表达被分析使用西式斑点.
通过流细胞计量量化Th17细胞分化,并通过免疫光定位RORγt表达.

主要成果:

在AIT小鼠中,BZYQ治疗显著减少了甲状腺结构损伤和淋巴细胞透.
服用BZYQ导致甲状腺蛋白抗体 (TGAb) 和甲状腺过氧化酶抗体 (TPOAb) 的血清水平降低.
BZYQ调节糖解,降低乳酸盐水平并减少Th17细胞的比例,同时上调PTEN表达以抑制PI3K/AKT通路和相关的糖解酶.

结论:

布忠益奇 (BZYQ) 通过向免疫代谢途径,在自身免疫性甲状腺炎 (AIT) 中显示出治疗效果.
BZYQ通过PTEN/AKT信号通路调节Th17细胞分化,为AIT提供了潜在的治疗策略.

关键词:

布忠益基 (Buzhong yiqi) 蒸煮剂 - - 这是一道蒸煮剂.在 PTEN/AKT 信号通道中.17 T 辅助细胞 17 自免疫性甲状腺炎的发生.免疫代谢的免疫代谢.

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