与MASLD患者相比,MAFLD患者的死亡率和心血管结果:系统性审查和元分析
Jiwon Yang1, Ye Rim Kim1, Seong Kyun Na2
1Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Gut and liver
|October 21, 2025
概括
代谢功能障碍相关的脂肪肝病 (MAFLD) 和代谢功能障碍相关的脂肪性肝病 (MASLD) 都会增加死亡率和心血管风险. 不同于MAFLD,MASLD在此元分析中与较高的癌症相关死亡率有关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 流行病学 流行病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 和与代谢功能障碍相关的脂肪性肝病 (MAFLD) 是非酒精性脂肪性肝病的最新术语.
- 有限的研究比较了MASLD和MAFLD的预后影响.
研究的目的:
- 量化MASLD,MAFLD和长期临床结果之间的关联.
- 为了比较MASLD与MAFLD对死亡率和心血管疾病发病率的预后影响.
主要方法:
- 在PubMed,Embase,Web of Science,CINAHL和CENTRAL进行了全面的文献搜索.
- 包括18项队列研究,涉及超过1000万被诊断患有MAFLD或MASLD的患者.
- 聚合危险比率 (HRs) 计算了所有原因死亡率,心血管死亡率,癌症相关死亡率和心血管疾病发病率.
主要成果:
- 无论是MAFLD还是MASLD,都与整体和心血管死亡率的增加有关.
- MAFLD显示整体死亡率 (HR 1.30) 和心血管死亡率 (HR 1.31) 的风险增加.
- MASLD显示总死亡率 (HR 1.34),心血管死亡率 (HR 1.17) 和癌症相关死亡率 (HR 1.24) 的风险增加.
- 在MAFLD (HR 1.48) 和MASLD (HR 1.33) 两种情况下,心血管疾病的风险增加.
结论:
- 无论是MAFLD还是MASLD,都与不良的长期结果有关,包括增加死亡率和心血管疾病风险.
- MASLD与与癌症相关的死亡率有显著的关联,而MAFLD则没有.
- 这些发现强调了在临床实践中区分MASLD和MAFLD的预后意义.
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