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患有涉及中枢神经系统的癌症的患者的神经认知功能
Martin Klein1,2, Denise D Correa3,4, Kyle R Noll5
1Cancer Center Amsterdam, Brain Tumor Center, Amsterdam, The Netherlands.
Journal of clinical and experimental neuropsychology
|October 21, 2025
概括
中枢神经系统 (CNS) 瘤经常导致神经认知缺陷,影响记忆力,注意力和执行功能. 瘤的位置和放射治疗等治疗方法显著加剧了这些损伤,需要个性化护理策略.
科学领域:
- 神经瘤学神经瘤学
- 认知神经科学 认知神经科学
背景情况:
- 中枢神经系统 (CNS) 瘤,包括原发性和转移性类型,会影响不同患者群体.
- 这些瘤,无论其来源如何,都构成神经认知障碍的重大风险,对与健康有关的生活质量 (HRQoL) 产生负面影响.
研究的目的:
- 审查和综合当前关于中枢神经系统瘤患者神经认知缺陷的文献.
- 检查瘤类型,位置和治疗方式对神经认知结果的影响.
主要方法:
- 在PubMed和Scopus进行了有针对性的文献搜索.
- 专注于质瘤,中枢神经系统原发性淋巴瘤和中枢神经系统转移性瘤的研究是根据临床相关性和方法质量进行选择的.
- 数据综合包括神经认知评估,患者人口统计和诸如大脑可塑性和心理痛苦之类的修饰因素.
主要成果:
- 神经认知缺陷,包括记忆,注意力,处理速度和执行功能的障碍,在中枢神经系统瘤患者中很普遍.
- 瘤的位置,特别是额叶和叶的参与,显著影响缺陷的严重程度.
- 放射治疗累计导致神经认知能力下降,而心理困扰和大脑弹性则调节结果.
结论:
- 神经认知障碍源于中枢神经系统瘤病理和治疗副作用.
- 了解这些机制对于开发有针对性的干预措施,如认知康复和个性化治疗计划至关重要.
- 优化HRQoL需要综合管理策略与神经保护方法和心理支持.
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