在自然食和饮酒期间,在口面感觉运动皮质中进行3D定向调整
Victoria B Hosack1, Fritzie Arce-McShane1,2,3
1Department of Oral Health Sciences, School of Dentistry, University of Washington, Seattle, United States.
eLife
|October 21, 2025
概括
研究人员研究了大脑如何控制饮食和饮酒期间的3D舌头运动. 他们发现,口面感觉运动皮质 (OSMCx) 编码了舌头的方向,这随着感觉损失而发生变化,为口语控制提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 感官处理 感官处理
背景情况:
- 在感觉运动皮质中对手臂运动的定向调整是众所周知的.
- 在自然行为过程中,口面感觉运动皮质 (OSMCx) 中对三维 (3D) 舌头运动的神经编码在很大程度上是未知的.
- 了解OSMCx功能对于治疗口腔语言功能障碍至关重要.
研究的目的:
- 调查在自然食和饮酒行为过程中OSMCx的定向调和人口动态.
- 为了检查感觉损失如何影响3D舌头运动的神经表现.
- 阐明在熟练控制舌头的基础上存在的神经机制.
主要方法:
- 使用双平面视频放射学来追踪在吃饭和喝水期间在 rhesus macaques 中植入的舌头标记物.
- 通过使用微电极阵列,从OSMCx的原发动机 (MIo) 和体感官 (SIo) 区域同时记录神经活动 (spiking).
- 研究了三神经对舌头运动和神经活动的感觉损失的影响.
主要成果:
- 大多数MIo和SIo神经元在饮食和饮食期间表现出对3D舌头方向的调制.
- 在食期间,方向信息更高,更强大,特别是在MIo.
- 感觉损失改变了舌头动力学,并导致MIo和SIo的方向信息发生变化,影响了个体神经元调节和群体动态.
结论:
- 包括MIo和SIo在内的OSMCx在编码自然行为期间的3D舌头运动中发挥着重要作用.
- 在OSMCx中神经表示是适应性的和特定于环境的,适应行为需求和感官反.
- 这些发现为口语感官运动控制的神经基础提供了关键的见解,并对康复策略产生影响.
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